PHENYL PANTOTHENONE, AN ANTAGONIST OF PANTOTHENIC ACID

Pantoylaminoethanethiol, an antagonist of pantothenic acid and pantetheine active in vitro and in the rat.

The compounds /3-d-pantoylaminoethanethiol (PAET) and the corresponding disulfide had been prepared by Barnett (1) in an attempt to find substances similar in structure to pantoyltaurine but more favorable in their inhibitory action on pantothenic acid-requiring microorganisms. Barnett showed that, although the compounds did inhibit the growth of Lactobacillus arabinosus to about the same exten...

Microbic Decomposition of Pantothenic Acid.

The metabolism of pantothenic acid.

The formulation of this pathway was based on: (a) the finding that cysteine supplies the sulfur-containing moiety of CoA (3,4); (b) the activities of pantetheine and pantothenylcysteine as growth factors for Acetobacter suboxydans (4-6) and Lactobacillus helveticus (7); (c) the presence of enzymes in these two organisms and also in Lactobacillus bulgur&s which decarboxylate pantothenylcysteine ...

Reye-like syndrome following treatment with the pantothenic acid antagonist, calcium hopantenate.

Three senile patients developed fatal acute encephalopathy while receiving calcium hopantenate. The clinical, biochemical, and pathological picture was similar to Reye's syndrome. Calcium hopantenate is a pantothenic acid antagonist. The serum levels of calcium hopantenate were high in coma, and that of pantothenic acid examined in one patient was lowered. Evidence obtained indicated that the R...

An assay for pantothenic acid in biologic fluids.

ANTOTHENIC ACID DEFICIENCY reduces biologic actylations and leads to a variety of pathologic changes in blood cholesterol partition and antibody production. Deficiency affects particularly the adrenal cortex, nervous system, the skin, and hair; it also affects longevity (1, 2, 3, 4). The ubiquity of pantothenic acid (as suggested by its name), makes it difficult to demonstrate deficiencies, eve...